Why does the same dose of morphine relieve some patients… but not others?
The MORPHEO project addresses this key issue.
At present, responses to morphine vary greatly from one patient to another: ineffectiveness, adverse effects or overdose may occur. This variability is due to biological and genetic factors, as well as factors linked to the disease itself.
MORPHEO’s aim is to gain a better understanding of these differences in order to tailor treatments to each patient.
To achieve this, the project combines:
- detailed analysis of how morphine is metabolised in the body,
- the study of genetic factors influencing response to treatment,
- innovative micro-sampling techniques (a single drop of blood),
- and artificial intelligence models to predict individual responses.
The results should help teams choose morphine doses more accurately, limit adverse effects and improve pain relief in the emergency department.
The aim?
A personalised approach to pain management that is more effective and safer.
In the longer term, MORPHEO could help teams anticipate each patient’s needs and provide safer, more effective pain treatment.
