Hydroxyurea and pregnancy

Pregnancy in women with sickle cell disease

Serious complications, preterm birth, frequent hospitalisations… despite advances, the risks remain significant, for both mother and child.

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A key question remains: is it safe to use hydroxyurea during pregnancy?

This treatment is currently the most effective at reducing complications of sickle cell disease, but it is often discontinued during pregnancy due to a lack of robust scientific data.

The HU & Pregnancy project aims to answer this crucial question.

Through a clinical trial comparing different management approaches, the teams are seeking to:

reduce maternal complications
improve the health of newborns
make medical practice safer

The aim?

To make pregnancies safer for women with sickle cell disease.

This project could lead to changes in medical guidelines and transform care provision on an international scale.

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Every donation funds direct action on the ground: equipping a screening centre, training a doctor or developing information tools for patients. Sickle cell disease affects millions of people but remains severely underfunded. Your support changes lives.

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Our projects

We run practical programmes to support earlier diagnosis, better care and wider access to information. Our projects cover research, prevention, therapeutic patient education and access to healthcare in the regions most affected by sickle cell disease.

View all projects

SCDiag

A simple, rapid and accessible approach to screening children for sickle cell disease at an early stage.

PRESEV 1 & PRESEV 2

Developing and validating a predictive score for acute chest syndrome.

PHARE Mayotte

Maintaining safe care for people with sickle cell disease, especially children, despite difficult living conditions.

MORPHEO

Understanding why patients respond differently to morphine, so treatment can be tailored to each person.

Hydroxyurea and pregnancy

A clinical study of hydroxyurea use during pregnancy.

PRESTA study

Improving care for people with sickle cell disease from the moment they arrive at the emergency department.

Drépagarde

Emergency childcare support to make hospital admission easier for single parents living with sickle cell disease.

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Our partners

RED is supported by a strong network of institutional, scientific and community partners. Within the RÊVE consortium and beyond, we combine our strengths to accelerate research and improve care wherever sickle cell disease occurs.